rs3758391(C;C)
Normal (worse) aging.
- Magnitude
- 2.0Worth knowing
- Repute
- Bad
- Frequency
- 30%Average of 11 populations
- On SNPedia
- rs3758391(C;C)
- Gene
- SIRT1
Frequency
Share of people with C;C in each HapMap population.
- European ancestry (Utah)55%
- Tuscan48%
- Yoruba (Nigeria)47%
- Maasai (Kenya)47%
- Luhya (Kenya)46%
- African ancestry (Southwest US)40%
- Mexican ancestry (Los Angeles)24%
- Gujarati Indian20%
- Han Chinese (Beijing)2%
- Japanese (Tokyo)<1%
- Chinese (Denver)<1%
Other genotypes of rs3758391
Notes
From SNPedia
This is the less beneficial version of the SIRT1 longevity gene, which doesn't extend lifespan. It is normal in non-Asians. It has more cognitive decline with age. Taking resveratrol is also believed to increase longevity via the SIRT1 gene, so it might (or might not) be possible to mitigate this with resveratrol supplements or some other SIRT1 activator.
Source and license
Adapted from rs3758391(C;C) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.