rs3758391(T;T)

Increased longevity. Less mental decline with age.

Magnitude
2.4Worth knowing
Repute
Good
Frequency
30%Average of 11 populations
On SNPedia
rs3758391(T;T)
Gene
SIRT1

Frequency

Share of people with T;T in each HapMap population.

  • Chinese (Denver)73%
  • Han Chinese (Beijing)65%
  • Japanese (Tokyo)65%
  • Gujarati Indian34%
  • Mexican ancestry (Los Angeles)33%
  • African ancestry (Southwest US)12%
  • Luhya (Kenya)12%
  • Maasai (Kenya)10%
  • European ancestry (Utah)9%
  • Yoruba (Nigeria)8%
  • Tuscan7%

Other genotypes of rs3758391

  1. C;CBadNormal (worse) aging.Worth knowing · 2.030% of people
  2. C;TGoodLess mental decline with age.Worth knowing · 2.040% of people

All about rs3758391

Notes

From SNPedia

This is the best version of the SIRT1 longevity gene. This may be one of the genes that causes Asians to live longer than other races, as it is common in Asians and rare elsewhere. It is also the target of anti-aging supplements like resveratrol.

Source and license

Adapted from rs3758391(T;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.