rs3758391

A SNP in the SIRT1 gene on chromosome 10. Its most notable genotype is T;T: Increased longevity. Less mental decline with age.

Gene
SIRT1
Location
Chr 1067,883,584 (GRCh38)
Highest magnitude
2.4Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CBadNormal (worse) aging.Worth knowing · 2.030% of people
  2. C;TGoodLess mental decline with age.Worth knowing · 2.040% of people
  3. T;TMost notableGoodIncreased longevity. Less mental decline with age.Worth knowing · 2.430% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 30% C;T 40% T;T 30%
  • European ancestry (Utah)C;C 55% C;T 36% T;T 9%
  • Han Chinese (Beijing)C;C 2% C;T 34% T;T 65%
  • Japanese (Tokyo)C;C <1% C;T 35% T;T 65%
  • Yoruba (Nigeria)C;C 47% C;T 45% T;T 8%
  • African ancestry (Southwest US)C;C 40% C;T 47% T;T 12%
  • Chinese (Denver)C;C <1% C;T 26% T;T 73%
  • Gujarati IndianC;C 20% C;T 47% T;T 34%
  • Luhya (Kenya)C;C 46% C;T 42% T;T 12%
  • Mexican ancestry (Los Angeles)C;C 24% C;T 43% T;T 33%
  • Maasai (Kenya)C;C 47% C;T 44% T;T 10%
  • TuscanC;C 48% C;T 45% T;T 7%

Other SIRT1 SNPs

All SIRT1 SNPs

Notes

From SNPedia

Show notes, about 220 words

rs3758391, a SNP in the SIRT1 gene, has been reported to potentially have some role in either longevity, or with higher statistical significance, better cognitive function in older individuals. SIRT1 is thought to regulate neuronal metabolism and survival in response to stress, and the equivalent gene in other species influences maximal life span. The study reporting improved cognition for carriers of rs3758391(T) alleles was based on over 1,000 Finnish adults over the age of 85, and a weak trend towards lower cardiovascular disease was also reported for this allele.

C;C

This is the less beneficial version of the SIRT1 longevity gene, which doesn't extend lifespan. It is normal in non-Asians. It has more cognitive decline with age. Taking resveratrol is also believed to increase longevity via the SIRT1 gene, so it might (or might not) be possible to mitigate this with resveratrol supplements or some other SIRT1 activator.

C;T

One copy of the good version of the SIRT1 longevity gene. This is believed to slow the aging of the brain, and perhaps to increase longevity.

T;T

This is the best version of the SIRT1 longevity gene. This may be one of the genes that causes Asians to live longer than other races, as it is common in Asians and rare elsewhere. It is also the target of anti-aging supplements like resveratrol.

Source and license

Adapted from rs3758391 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.