rs3758391(C;T)

Less mental decline with age.

Magnitude
2.0Worth knowing
Repute
Good
Frequency
40%Average of 11 populations
On SNPedia
rs3758391(C;T)
Gene
SIRT1

Frequency

Share of people with C;T in each HapMap population.

  • African ancestry (Southwest US)47%
  • Gujarati Indian47%
  • Tuscan45%
  • Yoruba (Nigeria)45%
  • Maasai (Kenya)44%
  • Mexican ancestry (Los Angeles)43%
  • Luhya (Kenya)42%
  • European ancestry (Utah)36%
  • Japanese (Tokyo)35%
  • Han Chinese (Beijing)34%
  • Chinese (Denver)26%

Other genotypes of rs3758391

  1. C;CBadNormal (worse) aging.Worth knowing · 2.030% of people
  2. T;TMost notableGoodIncreased longevity. Less mental decline with age.Worth knowing · 2.430% of people

All about rs3758391

Notes

From SNPedia

One copy of the good version of the SIRT1 longevity gene. This is believed to slow the aging of the brain, and perhaps to increase longevity.

Source and license

Adapted from rs3758391(C;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.