rs397516354
A SNP in the TNNI3 gene on chromosome 19. Its most notable genotype is A;C: Familial Hypertrophic Cardiomyopathy
- Gene
- TNNI3
- Location
- Chr 1955,154,094 (GRCh38)
- Highest magnitude
- 6.2Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- C;TBadFamilial hypertrophic cardiomyopathy (possible)
- C;CGoodcommon in clinvar
- A;CMost notableBadFamilial Hypertrophic Cardiomyopathy
SNPedia records rs397516354 on the minus strand: (A;G), (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other TNNI3 SNPs
- rs104894724C;GFamilial Hypertrophic CardiomyopathyVery important
- rs104894725G;TFamilial Hypertrophic CardiomyopathyVery important
- rs104894727C;TFamilial Hypertrophic CardiomyopathyVery important
- rs104894729C;TFamilial Hypertrophic CardiomyopathyVery important
- rs121917760A;GFamilial Hypertrophic CardiomyopathyVery important
- rs267607127C;TFamilial Hypertrophic CardiomyopathyVery important
- rs267607129C;GFamilial Hypertrophic CardiomyopathyVery important
- rs267607130G;TFamilial Hypertrophic CardiomyopathyVery important
Notes
From SNPedia
Notes
The rare minor allele of this variant is reported to be pathogenic/likely pathogenic for familial hypertrophic cardiomyopathy (HCM), according to .
C;T
see discussion at rs397516354
Source and license
Adapted from rs397516354 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.