rs398123278
A SNP in the MUT gene on chromosome 6. Its most notable genotype is A;A: Methylmalonic aciduria (predicted)
- Gene
- MUT
- Location
- Chr 649,459,376 (GRCh38)
- Highest magnitude
- 8.8Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- A;GBadCarrier for a methylmalonic aciduria mutation
- A;AMost notableBadMethylmalonic aciduria (predicted)
SNPedia records rs398123278 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other MUT SNPs
- rs121918248A;AMethylmalonic aciduria (predicted)Very important
- rs121918249G;GMethylmalonic aciduria (predicted)Very important
- rs121918251T;TMethylmalonic aciduria (predicted)Very important
- rs121918252A;AMethylmalonic aciduria (predicted)Very important
- rs121918253A;AMethylmalonic aciduria (predicted)Very important
- rs121918254T;TMethylmalonic aciduria (predicted)Very important
- rs121918256A;AMethylmalonic aciduria (predicted)Very important
- rs121918257A;AMethylmalonic aciduria (predicted)Very important
Notes
From SNPedia
Notes
A;G
See details via ClinVar link on main SNP/rs# page.
Source and license
Adapted from rs398123278 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.