rs420259
A SNP in the PALB2 gene on chromosome 16. Its most notable genotype is G;G: Half the risk of developing Bipolar Disorder.
- Gene
- PALB2
- Location
- Chr 1623,622,705 (GRCh38)
- Highest magnitude
- 1.9Minor
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 34%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GMost notableGoodHalf the risk of developing Bipolar Disorder.
- A;GGoodPossibly reduced risk of Bipolar Disorder.
- A;ABadNormal risk of Bipolar Disorder.
SNPedia records rs420259 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 14% A;G 44% A;A 42%
- European ancestry (Utah)G;G 4% A;G 31% A;A 65%
- Han Chinese (Beijing)G;G 15% A;G 48% A;A 37%
- Japanese (Tokyo)G;G 10% A;G 49% A;A 42%
- Yoruba (Nigeria)G;G 20% A;G 52% A;A 28%
- African ancestry (Southwest US)G;G 14% A;G 46% A;A 40%
- Chinese (Denver)G;G 14% A;G 49% A;A 38%
- Gujarati IndianG;G 10% A;G 39% A;A 52%
- Luhya (Kenya)G;G 25% A;G 45% A;A 31%
- Mexican ancestry (Los Angeles)G;G 7% A;G 36% A;A 57%
- Maasai (Kenya)G;G 33% A;G 49% A;A 18%
- TuscanG;G 3% A;G 43% A;A 54%
Related
Conditions, medicines and genes
Other PALB2 SNPs
- rs118203997T;TFanconi anemia, complementation group NVery important
- rs118203998C;CFanconi anemia, complementation group NVery important
- rs118203999A;AFanconi anemia, complementation group NVery important
- rs180177083A;AFanconi anemia, complementation group NVery important
- rs180177084-;-Fanconi anemia, complementation group NVery important
- rs180177085-;-Fanconi anemia, complementation group NVery important
- rs180177090-;-Fanconi anemia, complementation group NVery important
- rs180177091A;AFanconi anemia, complementation group NVery important
Notes
From SNPedia
Show notes, about 160 words
Linked to bipolar disorder in one of the most comprehensive studies in 2007. Risk allele with reference to dbSNP orientation is reported to be (T), with either one or two copies leading to an odds ratio of 2 (CI 1.6-2.7). Some replications, but in 2011 23andMe published as failed to replicate in Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies.
G;G
This seems to cause a 0.5x reduced risk of bipolar disorder, according to preliminary research.
A;G
This appears to lower the risk of Bipolar Disorder compared to the more common version of the gene, based on preliminary research.
A;A
This is the normal version that most people have. It seems to have a higher risk of bipolar disorder than the rare version, based on preliminary research.
Source and license
Adapted from rs420259 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.