rs420259(A;G)

Possibly reduced risk of Bipolar Disorder.

Magnitude
1.5Minor
Repute
Good
Frequency
44%Average of 11 populations
On SNPedia
rs420259(C;T)Minus strand
Gene
PALB2

Frequency

Share of people with A;G in each HapMap population.

  • Yoruba (Nigeria)52%
  • Maasai (Kenya)49%
  • Japanese (Tokyo)49%
  • Chinese (Denver)49%
  • Han Chinese (Beijing)48%
  • African ancestry (Southwest US)46%
  • Luhya (Kenya)45%
  • Tuscan43%
  • Gujarati Indian39%
  • Mexican ancestry (Los Angeles)36%
  • European ancestry (Utah)31%

Other genotypes of rs420259

  1. G;GMost notableGoodHalf the risk of developing Bipolar Disorder.Minor · 1.914% of people
  2. A;ABadNormal risk of Bipolar Disorder.Minor · 1.542% of people

All about rs420259

Notes

From SNPedia

This appears to lower the risk of Bipolar Disorder compared to the more common version of the gene, based on preliminary research.

Source and license

Adapted from rs420259(C;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.