rs420259(G;G)

Half the risk of developing Bipolar Disorder.

Magnitude
1.9Minor
Repute
Good
Frequency
14%Average of 11 populations
On SNPedia
rs420259(C;C)Minus strand
Gene
PALB2

Frequency

Share of people with G;G in each HapMap population.

  • Maasai (Kenya)33%
  • Luhya (Kenya)25%
  • Yoruba (Nigeria)20%
  • Han Chinese (Beijing)15%
  • African ancestry (Southwest US)14%
  • Chinese (Denver)14%
  • Gujarati Indian10%
  • Japanese (Tokyo)10%
  • Mexican ancestry (Los Angeles)7%
  • European ancestry (Utah)4%
  • Tuscan3%

Other genotypes of rs420259

  1. A;GGoodPossibly reduced risk of Bipolar Disorder.Minor · 1.544% of people
  2. A;ABadNormal risk of Bipolar Disorder.Minor · 1.542% of people

All about rs420259

Notes

From SNPedia

This seems to cause a 0.5x reduced risk of bipolar disorder, according to preliminary research.

Source and license

Adapted from rs420259(C;C) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.