rs431825410
A SNP in the BRCA1 gene on chromosome 17. Its most notable genotype is -;TAACT: BRCA1 variant considered pathogenic for breast cancer
- Gene
- BRCA1
- Location
- Chr 1743,067,652 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;TAACTMost notableBadBRCA1 variant considered pathogenic for breast cancer
- -;TTAACBadBRCA1 variant considered pathogenic for breast cancer
- TAACT;TAACTGoodcommon in clinvar
- TTAAC;TTAACGoodcommon in clinvar
On SNPedia: (-;TAACT), (-;TTAAC), (TAACT;TAACT), (TTAAC;TTAAC). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other BRCA1 SNPs
- rs28897696T;Tcarrier of two copies of BRCA1 variant; likely to be at high risk for breast/ovarian cancerVery important
- rs41286296A;CBRCA1 pathogenic mutation associated with breast cancerVery important
- rs62625306A;CBRCA1 pathogenic mutation associated with breast cancerVery important
- rs62625307A;GBRCA1 pathogenic mutation associated with breast cancerVery important
- i6051899A;Clikely to be BRCA1 variant pathogenic for breast cancerVery important
- rs1800747C;TBRCA1 pathogenic mutation associated with breast cancerVery important
- rs28897672A;Tconsidered a pathogenic BRCA1 breast cancer variantVery important
- rs28897686A;CBRCA1 pathogenic mutation associated with breast cancerVery important
Notes
From SNPedia
Notes
BRCA1, c.5026_5030delTTAAC (p.Leu1676Terfs) Note: ClinVar entry may not be current.
-;TAACT
see details via ClinVar sidebar/box on associated SNP/rs# page.
-;TTAAC
see details via ClinVar sidebar/box on associated SNP/rs# page
Source and license
Adapted from rs431825410 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.