rs4714156

A SNP in the BTBD9 gene on chromosome 6. Its most notable genotype is C;C: <0.61x risk for restless legs

Gene
BTBD9
Location
Chr 638,393,336 (GRCh38)
Highest magnitude
1.8Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
50%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGood<0.61x risk for restless legsMinor · 1.822% of people
  2. C;TNot rated0.61x risk for restless legsTypical · 0.042% of people
  3. T;TNot ratedcommonTypical · 0.036% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 22% C;T 42% T;T 36%
  • European ancestry (Utah)C;C 58% C;T 38% T;T 4%
  • Han Chinese (Beijing)C;C 2% C;T 29% T;T 70%
  • Japanese (Tokyo)C;C 4% C;T 29% T;T 67%
  • Yoruba (Nigeria)C;C 17% C;T 47% T;T 36%
  • African ancestry (Southwest US)C;C 9% C;T 48% T;T 43%
  • Chinese (Denver)C;C 4% C;T 35% T;T 62%
  • Gujarati IndianC;C 14% C;T 50% T;T 37%
  • Luhya (Kenya)C;C 19% C;T 50% T;T 32%
  • Mexican ancestry (Los Angeles)C;C 31% C;T 48% T;T 21%
  • Maasai (Kenya)C;C 34% C;T 48% T;T 18%
  • TuscanC;C 52% C;T 43% T;T 5%

Conditions, medicines and genes

Other BTBD9 SNPs

All BTBD9 SNPs

Notes

From SNPedia

Notes

rs4714156, a SNP located in the BTBD9 gene region, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.61 (CI: 0.51-0.74) for the (T) minor allele.

Source and license

Adapted from rs4714156 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.