rs9296249

A SNP in the BTBD9 gene on chromosome 6. Its most notable genotype is C;C: <0.62x risk for restless legs

Gene
BTBD9
Location
Chr 638,398,065 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
38%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot rated<0.62x risk for restless legsTypical · 0.017% of people
  2. C;TNot rated0.62x risk for restless legsTypical · 0.046% of people
  3. T;TNot ratedcommonTypical · 0.037% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 17% C;T 46% T;T 37%
  • European ancestry (Utah)C;C 4% C;T 39% T;T 58%
  • Han Chinese (Beijing)C;C 29% C;T 50% T;T 20%
  • Japanese (Tokyo)C;C 28% C;T 50% T;T 21%
  • Yoruba (Nigeria)C;C 20% C;T 48% T;T 32%
  • African ancestry (Southwest US)C;C 28% C;T 51% T;T 21%
  • Chinese (Denver)C;C 22% C;T 41% T;T 37%
  • Gujarati IndianC;C 15% C;T 45% T;T 41%
  • Luhya (Kenya)C;C 11% C;T 51% T;T 38%
  • Mexican ancestry (Los Angeles)C;C 21% C;T 48% T;T 31%
  • Maasai (Kenya)C;C 6% C;T 40% T;T 53%
  • TuscanC;C 5% C;T 43% T;T 52%

Conditions, medicines and genes

Other BTBD9 SNPs

All BTBD9 SNPs

Notes

From SNPedia

Notes

rs9296249, a SNP located in the BTBD9 gene region, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.62 (CI: 0.52-0.75) for the (C) minor allele. Homozygosity for the T-allele of BTBD9 rs9296249 was associated with lower serum ferritin. The odds ratio for low serum ferritin was 1.35 (95% confidence interval, 1.02-1.77; p=0.03) when comparing donors with the TT genotype with donors with the CT genotype.

Source and license

Adapted from rs9296249 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.