rs9357271

A SNP in the BTBD9 gene on chromosome 6. Its most notable genotype is T;T: Normal risk of developing restless legs syndrome

Gene
BTBD9
Location
Chr 638,398,097 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot rated<0.63x risk for restless legsTypical · 0.038% of people
  2. C;TNot rated0.63x risk for restless legsTypical · 0.042% of people
  3. T;TMost notableGoodNormal risk of developing restless legs syndromeMinor · 1.020% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 38% C;T 42% T;T 20%
  • European ancestry (Utah)C;C 4% C;T 38% T;T 58%
  • Han Chinese (Beijing)C;C 76% C;T 23% T;T <1%
  • Japanese (Tokyo)C;C 69% C;T 28% T;T 4%
  • Yoruba (Nigeria)C;C 37% C;T 51% T;T 12%
  • African ancestry (Southwest US)C;C 46% C;T 47% T;T 7%
  • Chinese (Denver)C;C 68% C;T 29% T;T 3%
  • Gujarati IndianC;C 37% C;T 50% T;T 14%
  • Luhya (Kenya)C;C 34% C;T 49% T;T 17%
  • Mexican ancestry (Los Angeles)C;C 29% C;T 52% T;T 19%
  • Maasai (Kenya)C;C 17% C;T 51% T;T 33%
  • TuscanC;C 5% C;T 44% T;T 51%

Conditions, medicines and genes

Other BTBD9 SNPs

All BTBD9 SNPs

Notes

From SNPedia

Notes

rs9357271, a SNP located in the BTBD9 gene region, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.63 (CI: 0.52-0.75) for the (C) minor allele. This SNP may also be associated with Tourette syndrome (TS), particularly TS without obsessive-compulsive disorder, based on a study of ~600 patients.

Source and license

Adapted from rs9357271 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.