rs9394492

A SNP in the BTBD9 gene on chromosome 6. Its most notable genotype is C;C: <0.76x risk for restless legs

Gene
BTBD9
Location
Chr 638,364,834 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
44%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGood<0.76x risk for restless legsTypical · 0.024% of people
  2. C;TGood0.76x risk for restless legsTypical · 0.038% of people
  3. T;TNot ratedcommonTypical · 0.038% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 24% C;T 38% T;T 38%
  • European ancestry (Utah)C;C 43% C;T 48% T;T 10%
  • Han Chinese (Beijing)C;C 0% C;T 12% T;T 88%
  • Japanese (Tokyo)C;C <1% C;T 25% T;T 74%
  • Yoruba (Nigeria)C;C 35% C;T 50% T;T 16%
  • African ancestry (Southwest US)C;C 32% C;T 63% T;T 5%
  • Chinese (Denver)C;C 0% C;T 8% T;T 92%
  • Gujarati IndianC;C 10% C;T 41% T;T 50%
  • Luhya (Kenya)C;C 45% C;T 39% T;T 16%
  • Mexican ancestry (Los Angeles)C;C 12% C;T 40% T;T 48%
  • Maasai (Kenya)C;C 56% C;T 39% T;T 5%
  • TuscanC;C 34% C;T 52% T;T 14%

Conditions, medicines and genes

Other BTBD9 SNPs

All BTBD9 SNPs

Notes

From SNPedia

Notes

rs9394492, a SNP located in the BTBD9 gene region, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.76 (CI: 0.64-0.87) for the (T) minor allele.

Source and license

Adapted from rs9394492 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.