rs4942486
A SNP in the BRCA2 gene on chromosome 13. Its most notable genotype is C;C: common/normal
- Gene
- BRCA2
- Location
- Chr 1332,379,251 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 26% C;T 50% T;T 24%
- European ancestry (Utah)C;C 26% C;T 41% T;T 34%
- Han Chinese (Beijing)C;C 26% C;T 53% T;T 21%
- Japanese (Tokyo)C;C 33% C;T 53% T;T 14%
- Yoruba (Nigeria)C;C 20% C;T 52% T;T 28%
- African ancestry (Southwest US)C;C 30% C;T 53% T;T 18%
- Chinese (Denver)C;C 28% C;T 51% T;T 21%
- Gujarati IndianC;C 29% C;T 48% T;T 24%
- Luhya (Kenya)C;C 28% C;T 46% T;T 26%
- Mexican ancestry (Los Angeles)C;C 19% C;T 62% T;T 19%
- Maasai (Kenya)C;C 18% C;T 50% T;T 32%
- TuscanC;C 31% C;T 46% T;T 23%
Related
Other BRCA2 SNPs
- i5009091D;Ilikely to be BRCA2 variant pathogenic for breast cancerVery important
- rs4987049A;CBRCA2 variant considered pathogenic for breast cancerVery important
- rs11571658-;TTBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897743A;Gconsidered a causal BRCA2 breast cancer mutationVery important
- rs28897746C;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897756A;ABRCA2, breast cancer mutationVery important
- rs41293477G;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs41293489C;GBRCA2 variant considered pathogenic for breast cancerVery important
Notes
From SNPedia
Notes
rs4942486, also known as c.8755-66T>C, is a variant in the BRCA2 gene classified as benign by at least two sources in ClinVar.
Source and license
Adapted from rs4942486 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.