rs543749

A SNP in the ADAM33 gene on chromosome 20. Its most notable genotype is G;G: If a smoker, higher risk risk for COPD in smokers in a Hispanic population.

Gene
ADAM33
Location
Chr 203,669,032 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe
Minor allele frequency
17%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBadIf a smoker, higher risk risk for COPD in smokers in a Hispanic population.Worth knowing · 2.1

On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other ADAM33 SNPs

All ADAM33 SNPs

Notes

From SNPedia

Notes

rs543749, also known as IVS21_22 or V-1, is a SNP in the ADAM metallopeptidase domain 33 ADAM33 gene. A study of ~600 non-Hispanic white males who smoked concluded that rs543749(G;G) carriers, i.e. those homozygous for the most common allele, were more likely (p< 0.0026, after Bonferroni correction) to develop chronic obstructive pulmonary disease (COPD) than carriers of one or two rs543749(T) alleles.

G;G

If a smoker, somewhat more likely to develop COPD.

Source and license

Adapted from rs543749 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.