rs6195

rs6195 (Asn363Ser/N363S) is a SNP within the NR3C1 (Nuclear receptor subfamily 3, group C, member 1 [glucocorticoid receptor]) gene. The common A allele encodes for Asparagine and the less common G allele encodes for Serine. Abstract linked to increased glucocorticoid sensitivity, coronary artery disease, and increased body mass index. Molecular evidence for a link between the N363S glucocorticoid receptor polymorphism and altered gene expression. Glucocorticoid receptor gene variant in the 3' untranslated region is associated with multiple measures of blood pressure. No association of glucocorticoid receptor polymorphisms with asthma and response to glucocorticoids. IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location. Pharmacogenetic risk factors for altered bone mineral density and body composition in pediatric acute lymphoblastic leukemia. Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study. Pharmacogenomic approaches to asthma treatment. Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease. Genetic polymorphisms of the glucocorticoid receptor may affect the phenotype of women with anovulatory polycystic ovary syndrome. Glucocorticoid receptor polymorphism is associated with lithium response in bipolar patients.