rs63750737
A SNP in the MSH2 gene on chromosome 2. Its most notable genotype is -;A: Lynch syndrome, pathogenic mutation
- Gene
- MSH2
- Location
- Chr 247,470,999 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;AMost notableBadLynch syndrome, pathogenic mutation
- -;AABadLynch syndrome, pathogenic mutation
- AA;AAGoodcommon in clinvar
On SNPedia: (-;A), (-;AA), (AA;AA). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other MSH2 SNPs
- rs63750245T;TLynch syndrome; hereditary nonpolyposis colorectal cancer-1Very important
- rs63750875C;CLynch syndrome; hereditary nonpolyposis colorectal cancer (HNPCC1)Very important
- rs63751449-;-Lynch syndrome; hereditary nonpolyposis colorectal cancer-1Very important
- rs12476364A;GLynch syndrome, pathogenic mutationVery important
- rs28929483C;TLynch syndrome, pathogenic mutationVery important
- rs28929484C;TLynch syndrome, pathogenic mutationVery important
- rs34986638G;TLynch syndrome, pathogenic mutationVery important
- rs63749802G;TLynch syndrome, pathogenic mutationVery important
Notes
From SNPedia
Notes
aka both c.1696_1697delAA and c.1697delA; both are considered in ClinVar to be pathogenic for Lynch syndrome
-;A
Note: if raw data is DI, exact mutation may be ambiguous.
-;AA
Note: if raw data is DI, exact mutation may be ambiguous.
Source and license
Adapted from rs63750737 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.