rs768130289
A SNP in the MUTYH gene on chromosome 1. Its most notable genotype is -;G: Carrier of a MUTYH-related familial adenomatous polyposis mutation
- Gene
- MUTYH
- Location
- Chr 145,331,745 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Goodcommon in clinvar
- -;GMost notableBadCarrier of a MUTYH-related familial adenomatous polyposis mutation
- -;GGBadCarrier of a MUTYH-related familial adenomatous polyposis mutation
- D;DGoodcommon genotype
- G;GGoodcommon/normal
- GG;GGGoodcommon/normal
On SNPedia: (-;-), (-;G), (-;GG), (D;D), (G;G), (GG;GG). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other MUTYH SNPs
- rs34612342C;Cincreased risk for several cancersVery important
- rs36053993T;Tlikely to be at somewhat increased risk for colorectal cancersVery important
- rs77542170C;Cautosomal recessive familial adenomatous polyposis-2 (FAP2)Very important
- rs200165598C;TPossible polyp associated variant, but of uncertain significanceVery important
- rs1060501342-;CCincreased risk for several cancersVery important
- rs121908380G;TCarrier of a MUTYH-related familial adenomatous polyposis mutationImportant
- rs121908381A;CCarrier of a MUTYH-related familial adenomatous polyposis mutationImportant
- rs143353451C;TCarrier of a MUTYH-related familial adenomatous polyposis mutationImportant
Notes
From SNPedia
Notes
at least three variants are now represented by rs768130289: c.1092delC, c.1091_1092delCC, and c.1092dupC; all are considered in ClinVar to be pathogenic for MYH-associated polyposis
-;G
Unaffected in absence of a second MUTYH gene mutation
-;GG
Unaffected in absence of a second MUTYH gene mutation
Source and license
Adapted from rs768130289 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.