rs80357093
A SNP in the BRCA1 gene on chromosome 17. Its most notable genotype is C;T: considered a pathogenic breast cancer variant
- Gene
- BRCA1
- Location
- Chr 1743,106,486 (GRCh38)
- Highest magnitude
- 4.0Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- C;TMost notableBadconsidered a pathogenic breast cancer variant
- C;CGoodcommon in clinvar
SNPedia records rs80357093 on the minus strand: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other BRCA1 SNPs
- rs28897696T;Tcarrier of two copies of BRCA1 variant; likely to be at high risk for breast/ovarian cancerVery important
- rs41286296A;CBRCA1 pathogenic mutation associated with breast cancerVery important
- rs62625306A;CBRCA1 pathogenic mutation associated with breast cancerVery important
- rs62625307A;GBRCA1 pathogenic mutation associated with breast cancerVery important
- i6051899A;Clikely to be BRCA1 variant pathogenic for breast cancerVery important
- rs1800747C;TBRCA1 pathogenic mutation associated with breast cancerVery important
- rs28897672A;Tconsidered a pathogenic BRCA1 breast cancer variantVery important
- rs28897686A;CBRCA1 pathogenic mutation associated with breast cancerVery important
Notes
From SNPedia
Notes
rs80357093 is a SNP causing an amino acid change in the breast cancer 1 BRCA1 gene at amino position 61. The more common rs80357093(G) allele (in dbSNP orientation) encodes Cys, while the rare rs80357093(A) allele encodes Tyr; this variation is also known as Cys61Tyr or C61Y. This variant is considered pathogenic for breast cancer by ClinVar's Sharing Clinical Reports Project.
C;T
This BRCA1 mutation is considered pathogenic (for breast cancer) by several sources, including ClinVar.
Source and license
Adapted from rs80357093 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.