rs1060500435
A SNP in the TTN gene on chromosome 2. Its most notable genotype is A;G: Dilated cardiomyopathy and/or early-onset atrial fibrillation (predicted)
- Gene
- TTN
- Location
- Chr 2178,546,612 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- Not on consumer chips
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- A;GMost notableBadDilated cardiomyopathy and/or early-onset atrial fibrillation (predicted)
SNPedia records rs1060500435 on the minus strand: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other TTN SNPs
- rs397517580A;GSome assertions re cardiac issues (see text)Very important
- rs28933405A;CFamilial Hypertrophic CardiomyopathyImportant
- rs202234172C;TPossible (silent?) cardiac issueWorth knowing
- rs368219776C;TPossible (silent?) cardiac issueWorth knowing
- rs770579313A;GPossible (silent?) cardiac issueWorth knowing
- rs869312089C;TPossible (silent?) cardiac issueWorth knowing
- rs869312091-;TPossible (silent?) cardiac issueWorth knowing
- rs869312092-;TPossible (silent?) cardiac issueWorth knowing
Notes
From SNPedia
Notes
aka c.94816C>T (p.Arg31606Ter) This mutation is considered in ClinVar to be a dominantly inherited mutation leading to either dilated cardiomyopathy or very early-onset atrial fibrillation; see also
A;G
see text and links via main rs-page
Source and license
Adapted from rs1060500435 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.