rs770579313
A SNP in the TTN gene on chromosome 2. Its most notable genotype is A;G: Possible (silent?) cardiac issue
- Gene
- TTN
- Location
- Chr 2178,724,117 (GRCh38)
- Highest magnitude
- 2.7Worth knowing
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;GMost notableBadPossible (silent?) cardiac issue
- G;GGoodcommon/normal
On SNPedia: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other TTN SNPs
- rs1060500435A;GDilated cardiomyopathy and/or early-onset atrial fibrillation (predicted)Very important
- rs397517580A;GSome assertions re cardiac issues (see text)Very important
- rs28933405A;CFamilial Hypertrophic CardiomyopathyImportant
- rs202234172C;TPossible (silent?) cardiac issueWorth knowing
- rs368219776C;TPossible (silent?) cardiac issueWorth knowing
- rs869312089C;TPossible (silent?) cardiac issueWorth knowing
- rs869312091-;TPossible (silent?) cardiac issueWorth knowing
- rs869312092-;TPossible (silent?) cardiac issueWorth knowing
Notes
From SNPedia
Notes
}} rs770579313, also known as c.21142C>T, p.Arg7048Ter and R7048X, is a rare mutation in the TTN gene. Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM), yet may be silently present in ~1% of the general population. This variant was observed in healthy humans, where machine-learning-based analysis of high-resolution cardiac imaging showed it to be associated with eccentric cardiac remodeling.
A;G
see discussion at rs770579313
Source and license
Adapted from rs770579313 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.