rs202234172
A SNP in the TTN gene on chromosome 2. Its most notable genotype is C;T: Possible (silent?) cardiac issue
- Gene
- TTN
- Location
- Chr 2178,689,897 (GRCh38)
- Highest magnitude
- 2.7Worth knowing
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon/normal
- C;TMost notableBadPossible (silent?) cardiac issue
On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other TTN SNPs
- rs1060500435A;GDilated cardiomyopathy and/or early-onset atrial fibrillation (predicted)Very important
- rs397517580A;GSome assertions re cardiac issues (see text)Very important
- rs28933405A;CFamilial Hypertrophic CardiomyopathyImportant
- rs368219776C;TPossible (silent?) cardiac issueWorth knowing
- rs770579313A;GPossible (silent?) cardiac issueWorth knowing
- rs869312089C;TPossible (silent?) cardiac issueWorth knowing
- rs869312091-;TPossible (silent?) cardiac issueWorth knowing
- rs869312092-;TPossible (silent?) cardiac issueWorth knowing
Notes
From SNPedia
Notes
rs202234172, also known as c.31763-1G>A, is a rare mutation in the TTN gene. Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM), yet may be silently present in ~1% of the general population. This variant was observed in healthy humans, where machine-learning-based analysis of high-resolution cardiac imaging showed it to be associated with eccentric cardiac remodeling.
C;T
see discussion at rs202234172
Source and license
Adapted from rs202234172 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.