rs397517580
A SNP in the TTN gene on chromosome 2. Its most notable genotype is A;G: Some assertions re cardiac issues (see text)
- Gene
- TTN
- Location
- Chr 2178,621,517 (GRCh38)
- Highest magnitude
- 4.1Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- A;GMost notableBadSome assertions re cardiac issues (see text)
SNPedia records rs397517580 on the minus strand: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other TTN SNPs
- rs1060500435A;GDilated cardiomyopathy and/or early-onset atrial fibrillation (predicted)Very important
- rs28933405A;CFamilial Hypertrophic CardiomyopathyImportant
- rs202234172C;TPossible (silent?) cardiac issueWorth knowing
- rs368219776C;TPossible (silent?) cardiac issueWorth knowing
- rs770579313A;GPossible (silent?) cardiac issueWorth knowing
- rs869312089C;TPossible (silent?) cardiac issueWorth knowing
- rs869312091-;TPossible (silent?) cardiac issueWorth knowing
- rs869312092-;TPossible (silent?) cardiac issueWorth knowing
Notes
From SNPedia
Notes
aka c.45307C>T (p.Arg15103Ter) Conflicting assertions in ClinVar about pathogenicity for dilated cardiomyopathy; also observed in a sudden cardiac death patient
A;G
see text and links via main rs-page
Source and license
Adapted from rs397517580 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.