rs1065489
A SNP in the CFH gene on chromosome 1. Its most notable genotype is G;G: common in clinvar
- Gene
- CFH
- Location
- Chr 1196,740,644 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 23%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 64%
- European ancestry (Utah)G;G 72%
- Han Chinese (Beijing)G;G 24%
- Japanese (Tokyo)G;G 28%
- Yoruba (Nigeria)G;G 95%
- African ancestry (Southwest US)G;G 84%
- Chinese (Denver)G;G 28%
- Gujarati IndianG;G 81%
- Luhya (Kenya)G;G 92%
- Mexican ancestry (Los Angeles)G;G 53%
- Maasai (Kenya)G;G 77%
- TuscanG;G 67%
Related
Other CFH SNPs
- rs1061170C;C5.9x risk for AMD; higher mortality among nonagenariansImportant
- rs1061147A;A2.76x increased risk for Age Related Macular Degeneration.Worth knowing
- rs380390G;Gincreased risk for ARMDWorth knowing
- rs1329428C;C2x increased risk for macular degenerationWorth knowing
- rs572515A;ANo summary available.Worth knowing
- rs800292G;G5% higher risk of Age related macular degenerationWorth knowing
- rs460184T;Tcommon in clinvarTypical
- rs460897G;GNo summary available.Typical
Notes
From SNPedia
Notes
Each copy of the less common T version of this SNP was associated with about 36% lower odds of meningococcal disease.
Source and license
Adapted from rs1065489 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.