rs11246226

A SNP in the DRD4 gene on chromosome 11. Its most notable genotype is A;C: decreased risk of schizophrenia in limited study

Gene
DRD4
Location
Chr 11641,191 (GRCh38)
Highest magnitude
1.2Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ABadincreased risk of schizophrenia in limited studyMinor · 1.029% of people
  2. A;CMost notableGooddecreased risk of schizophrenia in limited studyMinor · 1.246% of people
  3. C;CGooddecreased risk of schizophrenia in limited studyMinor · 1.024% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 29% A;C 46% C;C 24%
  • European ancestry (Utah)A;A 23% A;C 56% C;C 21%
  • Han Chinese (Beijing)A;A 61% A;C 35% C;C 4%
  • Japanese (Tokyo)A;A 55% A;C 36% C;C 9%
  • Yoruba (Nigeria)A;A 14% A;C 51% C;C 34%
  • African ancestry (Southwest US)A;A 14% A;C 61% C;C 25%
  • Chinese (Denver)A;A 57% A;C 36% C;C 7%
  • Gujarati IndianA;A 32% A;C 46% C;C 22%
  • Luhya (Kenya)A;A 7% A;C 40% C;C 54%
  • Mexican ancestry (Los Angeles)A;A 18% A;C 56% C;C 26%
  • Maasai (Kenya)A;A 18% A;C 46% C;C 37%
  • TuscanA;A 25% A;C 47% C;C 28%

Conditions, medicines and genes

Other DRD4 SNPs

All DRD4 SNPs

Notes

From SNPedia

Notes

Associated with schizophrenia in a study of Croatians. Due to the limited number and diversity of the studied population, more study is needed to confirm any link. The C allele was associated with an decreased risk of schizophrenia.

Source and license

Adapted from rs11246226 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.