rs587776842
A SNP in the DRD4 gene on chromosome 11. Its most notable genotype is -;-: Autonomic nervous system dysfunction?
- Gene
- DRD4
- Location
- Chr 11637,539 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Most notableBadAutonomic nervous system dysfunction?
- -;GCCGACCTCCTCCBadCarrier of DRD4 deletion allele
- CCGCCGACCTCCT;CCGCCGACCTCCTGoodcommon in clinvar
- GCCGACCTCCTCC;GCCGACCTCCTCCGoodcommon in clinvar
On SNPedia: (-;-), (-;GCCGACCTCCTCC), (CCGCCGACCTCCT;CCGCCGACCTCCT), (GCCGACCTCCTCC;GCCGACCTCCTCC). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Notes
From SNPedia
Notes
rs587776842, also known as c.235_247delGCCGACCTCCTCC, represents a rare deletion variant in the DRD4 gene on chromosome 11, encoding a nonfunctional DRD4 protein. The DRD4 protein is a G protein-coupled receptor belonging to the dopamine D2-like receptor family. A patient carrying two copies of the minor allele of rs587776842 was reported to have an autonomic nervous system dysfunction; see OMIM. Heterozygous individuals are not reported to be symptomatic.
-;-
See discussion at rs587776842 and related OMIM link
-;GCCGACCTCCTCC
see discussion at rs587776842
Source and license
Adapted from rs587776842 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.