rs1800443

A SNP in the DRD4 gene on chromosome 11. Its most notable genotype is G;G: Rare DRD4 polymorphism

Gene
DRD4
Location
Chr 11639,830 (GRCh38)
Highest magnitude
3.5Important
Tested on
23andMe, AncestryDNA
Minor allele frequency
1%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedRare DRD4 polymorphismImportant · 3.5<1% of people
  2. G;TNot ratedUncommon DRD4 polymorphismImportant · 3.05% of people
  3. T;TGoodcommon in clinvarTypical · 0.095% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 7 HapMap populations.

  • AverageG;G <1% G;T 5% T;T 95%
  • European ancestry (Utah)G;G 0% G;T 0% T;T 100%
  • Han Chinese (Beijing)G;G 0% G;T 0% T;T 100%
  • Japanese (Tokyo)G;G 0% G;T 0% T;T 100%
  • Yoruba (Nigeria)G;G <1% G;T 13% T;T 86%
  • African ancestry (Southwest US)G;G 0% G;T 16% T;T 84%
  • Luhya (Kenya)G;G 0% G;T 6% T;T 94%
  • Maasai (Kenya)G;G 0% G;T 3% T;T 97%

Conditions, medicines and genes

Other DRD4 SNPs

All DRD4 SNPs

Notes

From SNPedia

Notes

G;G

insensitive to dopamine and clozapine

Source and license

Adapted from rs1800443 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.