rs4331145

A SNP in the DRD4 gene on chromosome 11. Its most notable genotype is T;T: increased risk of schizophrenia in limited study

Gene
DRD4
Location
Chr 11643,683 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe
Minor allele frequency
45%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableNot ratedincreased risk of schizophrenia in limited studyMinor · 1.512% of people
  2. C;TNot rateddecreased risk of schizophrenia in limited studyMinor · 1.541% of people
  3. C;CNot ratedincreased risk of schizophrenia in limited studyTypical · 0.147% of people

SNPedia records rs4331145 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 3 HapMap populations.

  • AverageT;T 12% C;T 41% C;C 47%
  • European ancestry (Utah)T;T 28% C;T 57% C;C 15%
  • Han Chinese (Beijing)T;T 2% C;T 33% C;C 64%
  • Japanese (Tokyo)T;T 7% C;T 32% C;C 61%

Conditions, medicines and genes

Other DRD4 SNPs

All DRD4 SNPs

Notes

From SNPedia

Notes

Associated with schizophrenia in a study of Croatians. Due to the limited number and diversity of the studied population, more study is needed to confirm any link. The G allele was associated with a decreased risk of schizophrenia.

Source and license

Adapted from rs4331145 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.