rs1800955

A SNP in the DRD4 gene on chromosome 11. Its most notable genotype is C;C: increased susceptibility to novelty seeking

Gene
DRD4
Location
Chr 11636,784 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe
Minor allele frequency
37%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedincreased susceptibility to novelty seekingWorth knowing · 2.0
  2. C;TNot ratedincreased susceptibility to novelty seekingWorth knowing · 2.0
  3. T;TNot ratednormalTypical · 0.0

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other DRD4 SNPs

All DRD4 SNPs

Notes

From SNPedia

Show notes, about 260 words

rs1800955, also known as C-521T and -521C/T, is a variant in the promoter region upstream of the DRD4 gene on chromosome 11. g2b2mh blog C allele of rs1800955 DRD4 gene survives an analysis of several dozen studies on genetics and personality. Although small, the evidence from the final meta-analysis indicates that the C-521T may account for up to 3% of phenotypic variance. rs1800955 and rs1800443 are discussed in this article in the Atlantic Magazine as influencing personality. Impact of five SNPs in dopamine-related genes on executive function. Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients. Role of functional dopaminergic gene polymorphisms in the etiology of idiopathic intellectual disability. Role of gene-gene/gene-environment interaction in the etiology of eastern Indian ADHD probands. The Genetics of Anorexia Nervosa: Current Findings and Future Perspectives. Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint. Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network. Genetic associations with schizophrenia: meta-analyses of 12 candidate genes. Association and synergistic interaction between promoter variants of the DRD4 gene in Japanese schizophrenics.

C;T

changes in dopamine D4 receptor levels associated with ADHD, increased susceptibility to novelty seeking, may benefit from specific parenting techniques http://www.theatlantic.com/doc/200912/dobbs-orchid-gene

Source and license

Adapted from rs1800955 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.