rs1129703
A SNP in the MCPH1 gene on chromosome 8. Its most notable genotype is G;G: common in complete genomics
- Gene
- MCPH1
- Location
- Chr 86,447,173 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 31%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 44%
- European ancestry (Utah)G;G 62%
- Han Chinese (Beijing)G;G 67%
- Japanese (Tokyo)G;G 52%
- Yoruba (Nigeria)G;G 6%
- African ancestry (Southwest US)G;G 14%
- Chinese (Denver)G;G 66%
- Gujarati IndianG;G 62%
- Luhya (Kenya)G;G 4%
- Mexican ancestry (Los Angeles)G;G 74%
- Maasai (Kenya)G;G 16%
- TuscanG;G 66%
Related
Other MCPH1 SNPs
- rs930557G;Gcommon in clinvarTypical
- rs1129706G;Gcommon in complete genomicsTypical
- rs2034143G;Gcommon in complete genomicsTypical
- rs2442513T;Tcommon genotypeTypical
- rs2515569G;Gcommon in complete genomicsTypical
- rs2916733G;Gcommon in complete genomicsTypical
- rs12674488C;Ccommon in clinvarTypical
- rs17076812A;Acommon in complete genomicsTypical
Notes
From SNPedia
Notes
mentioned as potentially affecting grey matter volume, sample size tiny
Source and license
Adapted from rs1129703 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.