rs12674488
A SNP in the MCPH1 gene on chromosome 8. Its most notable genotype is C;C: common in clinvar
- Gene
- MCPH1
- Location
- Chr 86,480,785 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 14%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 73%
- European ancestry (Utah)C;C 66%
- Han Chinese (Beijing)C;C 66%
- Japanese (Tokyo)C;C 51%
- Yoruba (Nigeria)C;C 80%
- African ancestry (Southwest US)C;C 79%
- Chinese (Denver)C;C 66%
- Gujarati IndianC;C 70%
- Luhya (Kenya)C;C 91%
- Mexican ancestry (Los Angeles)C;C 88%
- Maasai (Kenya)C;C 80%
- TuscanC;C 72%
Related
Other MCPH1 SNPs
- rs930557G;Gcommon in clinvarTypical
- rs1129703G;Gcommon in complete genomicsTypical
- rs1129706G;Gcommon in complete genomicsTypical
- rs2034143G;Gcommon in complete genomicsTypical
- rs2442513T;Tcommon genotypeTypical
- rs2515569G;Gcommon in complete genomicsTypical
- rs2916733G;Gcommon in complete genomicsTypical
- rs17076812A;Acommon in complete genomicsTypical
Notes
From SNPedia
Notes
mentioned as potentially affecting grey matter volume, sample size tiny
Source and license
Adapted from rs12674488 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.