rs12476289
A SNP in the TTN gene on chromosome 2. Its most notable genotype is C;C: common in complete genomics
- Gene
- TTN
- Location
- Chr 2178,777,248 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 9%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageC;C 83%
- European ancestry (Utah)C;C 88%
- Han Chinese (Beijing)C;C 61%
- Japanese (Tokyo)C;C 61%
- Yoruba (Nigeria)C;C 100%
- African ancestry (Southwest US)C;C 98%
- Chinese (Denver)C;C 64%
- Gujarati IndianC;C 98%
- Luhya (Kenya)C;C 98%
- Mexican ancestry (Los Angeles)C;C 71%
- TuscanC;C 95%
Related
Other TTN SNPs
- rs1060500435A;GDilated cardiomyopathy and/or early-onset atrial fibrillation (predicted)Very important
- rs397517580A;GSome assertions re cardiac issues (see text)Very important
- rs28933405A;CFamilial Hypertrophic CardiomyopathyImportant
- rs202234172C;TPossible (silent?) cardiac issueWorth knowing
- rs368219776C;TPossible (silent?) cardiac issueWorth knowing
- rs770579313A;GPossible (silent?) cardiac issueWorth knowing
- rs869312089C;TPossible (silent?) cardiac issueWorth knowing
- rs869312091-;TPossible (silent?) cardiac issueWorth knowing
Source and license
Adapted from rs12476289 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.