rs12594287
A SNP in the CYP19A1 gene on chromosome 15. Its most notable genotype is G;G: common in complete genomics
- Gene
- CYP19A1
- Location
- Chr 1551,231,710 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 19%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 61%
- European ancestry (Utah)G;G 93%
- Han Chinese (Beijing)G;G 57%
- Japanese (Tokyo)G;G 50%
- Yoruba (Nigeria)G;G 45%
- African ancestry (Southwest US)G;G 44%
- Chinese (Denver)G;G 65%
- Gujarati IndianG;G 60%
- Luhya (Kenya)G;G 30%
- Mexican ancestry (Los Angeles)G;G 83%
- Maasai (Kenya)G;G 50%
- TuscanG;G 91%
Related
Other CYP19A1 SNPs
- rs78310315C;TUnaffected carrier of an aromatase deficiency mutationImportant
- rs4646A;Acommon in clinvarTypical
- rs10046G;Gcommon in clinvarTypical
- rs700518T;Tcommon in clinvarTypical
- rs700519G;Gcommon in complete genomicsTypical
- rs1062033C;Gincreases susceptibility to postmenopausal osteoporosisTypical
- rs1902584A;Acommon in complete genomicsTypical
- rs1961177C;Ccommon in complete genomicsTypical
Notes
From SNPedia
Notes
The research paper suggests that the 3 snps rs17703883, rs12594287 and rs16964201 affect bone mineral density in men.
Source and license
Adapted from rs12594287 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.