rs12721629

A SNP in the CYP3A4 gene on chromosome 7. Its most notable genotype is A;A: CYP3A4*12 homozygote

Gene
CYP3A4
Location
Chr 799,762,177 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
AncestryDNA
Minor allele frequency
<1%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodnormalTypical · 0.099% of people
  2. A;GNot ratedcarrier of one CYP3A4*12 alleleTypical · 0.01% of people
  3. A;AMost notableNot ratedCYP3A4*12 homozygoteWorth knowing · 2.50% of people

SNPedia records rs12721629 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 6 HapMap populations.

  • AverageG;G 99% A;G 1% A;A 0%
  • European ancestry (Utah)G;G 100% A;G 0% A;A 0%
  • Han Chinese (Beijing)G;G 99% A;G <1% A;A 0%
  • Japanese (Tokyo)G;G 100% A;G 0% A;A 0%
  • Yoruba (Nigeria)G;G 98% A;G 2% A;A 0%
  • Luhya (Kenya)G;G 96% A;G 5% A;A 0%
  • Maasai (Kenya)G;G 99% A;G <1% A;A 0%

Other CYP3A4 SNPs

All CYP3A4 SNPs

Notes

From SNPedia

Notes

rs12721629, also known as 1117C>T, 21896C>T or L373F, is a SNP in the CYP3A4 gene. The rs12721629(T) allele defines the CYP3A4*12 variant. This SNP includes a SNP formerly known as rs45614732 that has now been merged into it.

Source and license

Adapted from rs12721629 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.