rs4646437
A SNP in the CYP3A4 gene on chromosome 7. Its most notable genotype is G;G: common in complete genomics
- Gene
- CYP3A4
- Location
- Chr 799,767,460 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 27%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs4646437 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 48%
- European ancestry (Utah)G;G 83%
- Han Chinese (Beijing)G;G 76%
- Japanese (Tokyo)G;G 79%
- Yoruba (Nigeria)G;G 1%
- African ancestry (Southwest US)G;G 12%
- Chinese (Denver)G;G 75%
- Gujarati IndianG;G 48%
- Luhya (Kenya)G;G 0%
- Mexican ancestry (Los Angeles)G;G 60%
- Maasai (Kenya)G;G 15%
- TuscanG;G 82%
Related
Other CYP3A4 SNPs
- rs67666821T;TCYP3A4*20 homozygote; side effects likely from many drugsVery important
- rs12721629A;ACYP3A4*12 homozygoteWorth knowing
- rs1041988G;GCYP3A4*_23139T>C(I431T) homozygoteTypical
- rs2242480C;CnormalTypical
- rs3091339T;TnormalTypical
- rs3208361T;TnormalTypical
- rs3208363C;CCYP3A4*_16907T>G(S252A) homozygoteTypical
- rs4646440G;Gcommon in complete genomicsTypical
Notes
From SNPedia
Notes
Sex-dependent genetic markers of CYP3A4 expression and activity in human liver microsomes. Prediction of CYP3A4 enzyme activity using haplotype tag SNPs in African Americans. CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients.
Source and license
Adapted from rs4646437 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.