rs3208363

A SNP in the CYP3A4 gene on chromosome 7. Its most notable genotype is C;C: CYP3A4*_16907T>G(S252A) homozygote

Gene
CYP3A4
Location
Chr 799,767,175 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedCYP3A4*_16907T>G(S252A) homozygoteTypical · 0.0<1% of people
  2. A;CNot ratedcarrier of one CYP3A4*_16907T>G(S252A) alleleTypical · 0.01% of people
  3. A;AGoodnormalTypical · 0.099% of people

SNPedia records rs3208363 on the minus strand: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageC;C <1% A;C 1% A;A 99%
  • European ancestry (Utah)C;C 0% A;C 0% A;A 100%
  • Han Chinese (Beijing)C;C 0% A;C 0% A;A 100%
  • Japanese (Tokyo)C;C 0% A;C 0% A;A 100%
  • Yoruba (Nigeria)C;C 0% A;C 0% A;A 100%
  • African ancestry (Southwest US)C;C 0% A;C 5% A;A 95%
  • Chinese (Denver)C;C 0% A;C 1% A;A 99%
  • Gujarati IndianC;C 0% A;C 1% A;A 99%
  • Luhya (Kenya)C;C <1% A;C 2% A;A 97%
  • Mexican ancestry (Los Angeles)C;C 0% A;C 2% A;A 98%
  • TuscanC;C 0% A;C 1% A;A 99%

Other CYP3A4 SNPs

All CYP3A4 SNPs

Notes

From SNPedia

Notes

rs3208363 is a SNP in the CYP3A4 gene. The rs3208363(G) allele defines the CYP3A4*_16907T>G(S252A) variant.

Source and license

Adapted from rs3208363 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.