rs3091339
A SNP in the CYP3A4 gene on chromosome 7. Its most notable genotype is T;T: normal
- Gene
- CYP3A4
- Location
- Chr 799,772,622 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableGoodnormal
- C;TNot ratedcarrier of one CYP3A4*_11460A>G(K96E) allele
- C;CNot ratedCYP3A4*_11460A>G(K96E) homozygote
SNPedia records rs3091339 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 6 HapMap populations.
- AverageT;T 99% C;T <1% C;C 0%
- European ancestry (Utah)T;T 100% C;T 0% C;C 0%
- Han Chinese (Beijing)T;T 99% C;T <1% C;C 0%
- Japanese (Tokyo)T;T 100% C;T 0% C;C 0%
- Yoruba (Nigeria)T;T 99% C;T <1% C;C 0%
- African ancestry (Southwest US)T;T 98% C;T 2% C;C 0%
- Mexican ancestry (Los Angeles)T;T 98% C;T 2% C;C 0%
Related
Other CYP3A4 SNPs
- rs67666821T;TCYP3A4*20 homozygote; side effects likely from many drugsVery important
- rs12721629A;ACYP3A4*12 homozygoteWorth knowing
- rs1041988G;GCYP3A4*_23139T>C(I431T) homozygoteTypical
- rs2242480C;CnormalTypical
- rs3208361T;TnormalTypical
- rs3208363C;CCYP3A4*_16907T>G(S252A) homozygoteTypical
- rs4646437G;Gcommon in complete genomicsTypical
- rs4646440G;Gcommon in complete genomicsTypical
Notes
From SNPedia
Notes
rs3091339 is a SNP in the CYP3A4 gene. The rs3091339(G) allele defines the CYP3A4*_11460A>G(K96E) variant.
Source and license
Adapted from rs3091339 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.