rs2242480
A SNP in the CYP3A4 gene on chromosome 7. Its most notable genotype is C;C: normal
- Gene
- CYP3A4
- Location
- Chr 799,763,843 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 33%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableGoodnormal
- C;TNot ratedcarrier of one CYP3A4*_20239G>A allele
- T;TNot ratedCYP3A4*_20239G>A homozygote
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 9 HapMap populations.
- AverageC;C 34% C;T 36% T;T 30%
- European ancestry (Utah)C;C 85% C;T 15% T;T 0%
- Han Chinese (Beijing)C;C 57% C;T 35% T;T 8%
- Japanese (Tokyo)C;C 47% C;T 48% T;T 5%
- Yoruba (Nigeria)C;C 1% C;T 23% T;T 75%
- African ancestry (Southwest US)C;C 11% C;T 43% T;T 46%
- Gujarati IndianC;C 46% C;T 44% T;T 10%
- Luhya (Kenya)C;C 2% C;T 21% T;T 77%
- Mexican ancestry (Los Angeles)C;C 35% C;T 47% T;T 18%
- Maasai (Kenya)C;C 21% C;T 46% T;T 33%
Related
Other CYP3A4 SNPs
- rs67666821T;TCYP3A4*20 homozygote; side effects likely from many drugsVery important
- rs12721629A;ACYP3A4*12 homozygoteWorth knowing
- rs1041988G;GCYP3A4*_23139T>C(I431T) homozygoteTypical
- rs3091339T;TnormalTypical
- rs3208361T;TnormalTypical
- rs3208363C;CCYP3A4*_16907T>G(S252A) homozygoteTypical
- rs4646437G;Gcommon in complete genomicsTypical
- rs4646440G;Gcommon in complete genomicsTypical
Notes
From SNPedia
Notes
rs2242480 is a SNP in the CYP3A4 gene. The rs2242480(T) allele defines the CYP3A4*_20239G>A variant.
Source and license
Adapted from rs2242480 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.