rs165688
A SNP in the COMT gene on chromosome 22. Its most notable genotype is G;G.
- Gene
- COMT
- Location
- Chr 2219,963,748 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 45%
- European ancestry (Utah)G;G 29%
- Han Chinese (Beijing)G;G 53%
- Japanese (Tokyo)G;G 48%
- Yoruba (Nigeria)G;G 48%
- African ancestry (Southwest US)G;G 58%
- Chinese (Denver)G;G 52%
- Gujarati IndianG;G 36%
- Luhya (Kenya)G;G 50%
- Mexican ancestry (Los Angeles)G;G 41%
- Maasai (Kenya)G;G 54%
- TuscanG;G 29%
Related
Other COMT SNPs
- rs4680A;A(worrier) advantage in memory and attention tasksWorth knowing
- rs4633C;Thigher risk for endometrial cancerWorth knowing
- rs165631C;TPerhaps slightly lower risk for breast cancer in BRCA1/2 mutation carriers?Minor
- rs6267G;GcommonTypical
- rs737865C;TNo summary available.Typical
- rs740602G;Gcommon in complete genomicsTypical
- rs769224G;GNo summary available.Typical
- rs8192488C;Ccommon in complete genomicsTypical
Notes
From SNPedia
Notes
(via g2b2mh blog) rs165688 correlated with preferences for immediate reward and brain activation.
Source and license
Adapted from rs165688 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.