rs4633
A SNP in the COMT gene on chromosome 22. Its most notable genotype is C;T: higher risk for endometrial cancer
- Gene
- COMT
- Location
- Chr 2219,962,712 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 39%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodnormal
- C;TMost notableBadhigher risk for endometrial cancer
- T;TBadhigher risk for endometrial cancer
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 44% C;T 42% T;T 14%
- European ancestry (Utah)C;C 29% C;T 46% T;T 25%
- Han Chinese (Beijing)C;C 53% C;T 37% T;T 10%
- Japanese (Tokyo)C;C 50% C;T 43% T;T 6%
- Yoruba (Nigeria)C;C 48% C;T 40% T;T 12%
- African ancestry (Southwest US)C;C 53% C;T 32% T;T 16%
- Chinese (Denver)C;C 52% C;T 43% T;T 5%
- Gujarati IndianC;C 37% C;T 42% T;T 22%
- Luhya (Kenya)C;C 48% C;T 40% T;T 12%
- Mexican ancestry (Los Angeles)C;C 40% C;T 48% T;T 12%
- Maasai (Kenya)C;C 46% C;T 45% T;T 10%
- TuscanC;C 29% C;T 50% T;T 21%
Related
Conditions, medicines and genes
Other COMT SNPs
- rs4680A;A(worrier) advantage in memory and attention tasksWorth knowing
- rs165631C;TPerhaps slightly lower risk for breast cancer in BRCA1/2 mutation carriers?Minor
- rs6267G;GcommonTypical
- rs165688G;GNo summary available.Typical
- rs737865C;TNo summary available.Typical
- rs740602G;Gcommon in complete genomicsTypical
- rs769224G;GNo summary available.Typical
- rs8192488C;Ccommon in complete genomicsTypical
Genosets
- Gs232Possible low pain sensitivity; LPS/LPSMinor
- Gs233Normal pain sensitivity; APS/APS, LPS/APS, and APS/HPS diplotypesMinor
- Gs234Possible high pain sensitivity; HPS/HPS or HPS/APSMinor
- Gs235Unclassified pain sensitivityTypical
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
rs4633 is a variant at codon 62 of the COMT gene, however, it does not change the amino acid sequence of the COMT protein. In a study of 150 (Caucasian) cases of endometrial cancer, a significant increase in rs4633(T;T) genotype was observed in patients compared to controls (OR = 2.39, CI: 1.31-4.37, p = 0.004). Furthemore, the frequency of the C-G haplotype of rs4633-rs4680 was significantly higher in controls (p < 0.0001) than in patients. This correlated with lower expression levels of the COMT protein in carriers of these alleles. pubmed 1180576 Schizophrenia Susceptibility Genetic basis for individual variations in pain perception and the development of a chronic pain condition
Source and license
Adapted from rs4633 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.