rs8192488
A SNP in the COMT gene on chromosome 22. Its most notable genotype is C;C: common in complete genomics
- Gene
- COMT
- Location
- Chr 2219,963,714 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 2%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;C 80%
- Yoruba (Nigeria)C;C 85%
- African ancestry (Southwest US)C;C 86%
- Luhya (Kenya)C;C 76%
- Maasai (Kenya)C;C 73%
Related
Other COMT SNPs
- rs4680A;A(worrier) advantage in memory and attention tasksWorth knowing
- rs4633C;Thigher risk for endometrial cancerWorth knowing
- rs165631C;TPerhaps slightly lower risk for breast cancer in BRCA1/2 mutation carriers?Minor
- rs6267G;GcommonTypical
- rs165688G;GNo summary available.Typical
- rs737865C;TNo summary available.Typical
- rs740602G;Gcommon in complete genomicsTypical
- rs769224G;GNo summary available.Typical
Notes
From SNPedia
Notes
Direct molecular haplotyping of multiple polymorphisms within exon 4 of the human catechol-O-methyltransferase gene by liquid chromatography-electrospray ionization time-of-flight mass spectrometry.
Source and license
Adapted from rs8192488 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.