rs737865

A SNP in the COMT gene on chromosome 22. Its most notable genotype is C;T.

Gene
COMT
Location
Chr 2219,942,598 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
24%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;TMost notableNot ratedNo summary available.Typical · 0.00% of people

SNPedia records rs737865 on the minus strand: (A;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;T 0%
  • European ancestry (Utah)C;T 0%
  • Han Chinese (Beijing)C;T 0%
  • Japanese (Tokyo)C;T 0%
  • Yoruba (Nigeria)C;T 0%
  • African ancestry (Southwest US)C;T 0%
  • Chinese (Denver)C;T 0%
  • Gujarati IndianC;T 0%
  • Luhya (Kenya)C;T 0%
  • Mexican ancestry (Los Angeles)C;T 0%
  • Maasai (Kenya)C;T 0%
  • TuscanC;T 0%

Conditions, medicines and genes

Other COMT SNPs

All COMT SNPs

Notes

From SNPedia

Notes

part of a three marker haplotype rs737865-rs4680-rs165599 COMT haplotypes at rs737865 and rs165599 may predict a favorable outcome for bupropion treatment for smoking cessation. We have typed the IVS 1 rs737865 and 3' rs615599 sites and also included a novel IVS 1 indel polymorphism. We report that the schizophrenia-associated haplotype is significantly heterogeneous in populations worldwide. may affect non-Hodgkin lymphoma, anxiety-related personality traits Also mentioned in these PMIDs * * * * * *

Source and license

Adapted from rs737865 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.