rs6267

A SNP in the COMT gene on chromosome 22. Its most notable genotype is G;G: common

Gene
COMT
Location
Chr 2219,962,740 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
2%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommonTypical · 0.094% of people
  2. G;TNot ratedNo summary available.Typical · 0.06% of people
  3. T;TNot ratedNo summary available.Typical · 0.0<1% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 94% G;T 6% T;T <1%
  • European ancestry (Utah)G;G 98% G;T 2% T;T 0%
  • Han Chinese (Beijing)G;G 86% G;T 12% T;T 2%
  • Japanese (Tokyo)G;G 88% G;T 12% T;T 0%
  • Yoruba (Nigeria)G;G 100% G;T 0% T;T 0%
  • African ancestry (Southwest US)G;G 96% G;T 4% T;T 0%
  • Chinese (Denver)G;G 94% G;T 6% T;T 0%
  • Gujarati IndianG;G 99% G;T 1% T;T 0%
  • Luhya (Kenya)G;G 91% G;T 9% T;T 0%
  • Mexican ancestry (Los Angeles)G;G 87% G;T 13% T;T 0%
  • Maasai (Kenya)G;G 96% G;T 4% T;T 0%
  • TuscanG;G 98% G;T 2% T;T 0%

Other COMT SNPs

All COMT SNPs

Source and license

Adapted from rs6267 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.