rs16866412
A SNP in the TTN gene on chromosome 2. Its most notable genotype is G;G: common in clinvar
- Gene
- TTN
- Location
- Chr 2178,609,941 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 86%
- European ancestry (Utah)G;G 97%
- Han Chinese (Beijing)G;G 72%
- Japanese (Tokyo)G;G 69%
- Yoruba (Nigeria)G;G 91%
- African ancestry (Southwest US)G;G 88%
- Chinese (Denver)G;G 77%
- Gujarati IndianG;G 94%
- Luhya (Kenya)G;G 77%
- Mexican ancestry (Los Angeles)G;G 98%
- Maasai (Kenya)G;G 88%
- TuscanG;G 94%
Related
Other TTN SNPs
- rs1060500435A;GDilated cardiomyopathy and/or early-onset atrial fibrillation (predicted)Very important
- rs397517580A;GSome assertions re cardiac issues (see text)Very important
- rs28933405A;CFamilial Hypertrophic CardiomyopathyImportant
- rs202234172C;TPossible (silent?) cardiac issueWorth knowing
- rs368219776C;TPossible (silent?) cardiac issueWorth knowing
- rs770579313A;GPossible (silent?) cardiac issueWorth knowing
- rs869312089C;TPossible (silent?) cardiac issueWorth knowing
- rs869312091-;TPossible (silent?) cardiac issueWorth knowing
Source and license
Adapted from rs16866412 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.