rs16947
A SNP in the LOC102723722 gene on chromosome 22. Its most notable genotype is A;G: a common variant
- Gene
- LOC102723722
- Location
- Chr 2242,127,941 (GRCh38)
- Highest magnitude
- 0.1Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 34%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AGoodHomozygous for CYP2D6 variants (non-CYP2D6*1)
- A;GMost notableNot rateda common variant
- G;GNot ratednormal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other LOC102723722 SNPs
- rs1135824C;CTwo copies of CYP2D6*3B non-functioning variantVery important
- rs5030867G;GCYP2D6*7 homozygoteVery important
- rs1065852A;AHomozygous for CYP2D6 decreased or non-functioning variants; possibly less response to some drugs, including tamoxifenImportant
- rs3892097T;TCYP2D6 poor metabolizer; many associations related to drug metabolismImportant
- rs5030655-;-CYP2D6*6 poor metabolizer phenotypeImportant
- rs28371733G;GHomozygous for non-functioning CYP2D6*4H variant.Important
- rs72549354C;CTwo CYP2D6*20 alleles; significantly lowered metabolism of certain drugsImportant
- rs1135840G;GHomozygous for CYP2D6 variants (non-CYP2D6*1)Worth knowing
Genosets
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
The wild type (normal) allele at this SNP is (G). The (A) variant indicates the presence of a non-wild type CYP2D6 variant, but it appears in many different variants so it can not be used to determine the presence of any particular variant. Inheriting a normal number of copies of this allele results in CYP2D6 function that is indistinguishable from wild-type (normal) activity. However, this variant has been seen present in higher copy numbers, and in these cases, can result in the ultrafast metabolizer phenotype .
Source and license
Adapted from rs16947 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.