rs5030655
A SNP in the LOC102723722 gene on chromosome 22. Its most notable genotype is -;-: CYP2D6*6 poor metabolizer phenotype
- Gene
- LOC102723722
- Location
- Chr 2242,129,084 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 1%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- -;-Most notableNot ratedCYP2D6*6 poor metabolizer phenotype
- -;ANot ratedpossible CYP2D6 poor metabolizer phenotype
- A;AGoodnormal
SNPedia records rs5030655 on the minus strand: (-;-), (-;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other LOC102723722 SNPs
- rs1135824C;CTwo copies of CYP2D6*3B non-functioning variantVery important
- rs5030867G;GCYP2D6*7 homozygoteVery important
- rs1065852A;AHomozygous for CYP2D6 decreased or non-functioning variants; possibly less response to some drugs, including tamoxifenImportant
- rs3892097T;TCYP2D6 poor metabolizer; many associations related to drug metabolismImportant
- rs28371733G;GHomozygous for non-functioning CYP2D6*4H variant.Important
- rs72549354C;CTwo CYP2D6*20 alleles; significantly lowered metabolism of certain drugsImportant
- rs1135840G;GHomozygous for CYP2D6 variants (non-CYP2D6*1)Worth knowing
- rs5030656-;-CYP2D6*9 homozygoteWorth knowing
Genosets
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
The (-) form of this SNP, representing a deletion of one nucleotide, causes a frameshift such that the resulting CYP2D6 protein is nonfunctional. The associated allele is also known as CYP2D6*6, and there are several subtypes but they are all nonfunctional. If two copies of this (or similar) changes are inherited, CYP2D6 poor metabolism ('PM') is observed. CYP2D6 poor metabolism may affect the efficacy or degree of side effects of drugs metabolized by CYP2D6, such as dextromorphan, sparteine, nortriptyline, venlafaxine and codeine. Response to serotonin reuptake inhibitors in OCD is not influenced by common CYP2D6 polymorphisms.
Source and license
Adapted from rs5030655 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.