rs5030656
A SNP in the LOC102723722 gene on chromosome 22. Its most notable genotype is -;-: CYP2D6*9 homozygote
- Gene
- LOC102723722
- Location
- Chr 2242,128,174 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Most notableNot ratedCYP2D6*9 homozygote
- -;AAGNot ratedcarrier of one CYP2D6*9 allele
- AAG;AAGGoodnormal
On SNPedia: (-;-), (-;AAG), (AAG;AAG). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other LOC102723722 SNPs
- rs1135824C;CTwo copies of CYP2D6*3B non-functioning variantVery important
- rs5030867G;GCYP2D6*7 homozygoteVery important
- rs1065852A;AHomozygous for CYP2D6 decreased or non-functioning variants; possibly less response to some drugs, including tamoxifenImportant
- rs3892097T;TCYP2D6 poor metabolizer; many associations related to drug metabolismImportant
- rs5030655-;-CYP2D6*6 poor metabolizer phenotypeImportant
- rs28371733G;GHomozygous for non-functioning CYP2D6*4H variant.Important
- rs72549354C;CTwo CYP2D6*20 alleles; significantly lowered metabolism of certain drugsImportant
- rs1135840G;GHomozygous for CYP2D6 variants (non-CYP2D6*1)Worth knowing
Genosets
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
rs5030656, also known as 2615_2617delAAG or K281del, is a SNP in the CYP2D6 gene. The rs5030656(-) allele defines the CYP2D6*9 variant, which has decreased activity.
-;AAG
one low functioning allele *9 allele
AAG;AAG
normal
Source and license
Adapted from rs5030656 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.