rs72549354
A SNP in the LOC102723722 gene on chromosome 22. Its most notable genotype is C;C: Two CYP2D6*20 alleles; significantly lowered metabolism of certain drugs
- Gene
- LOC102723722
- Location
- Chr 2242,128,817 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Goodcommon/normal
- -;CBadone CYP2D6*20 allele; lowered metabolism of certain drugs
- C;CMost notableBadTwo CYP2D6*20 alleles; significantly lowered metabolism of certain drugs
On SNPedia: (-;-), (-;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other LOC102723722 SNPs
- rs1135824C;CTwo copies of CYP2D6*3B non-functioning variantVery important
- rs5030867G;GCYP2D6*7 homozygoteVery important
- rs1065852A;AHomozygous for CYP2D6 decreased or non-functioning variants; possibly less response to some drugs, including tamoxifenImportant
- rs3892097T;TCYP2D6 poor metabolizer; many associations related to drug metabolismImportant
- rs5030655-;-CYP2D6*6 poor metabolizer phenotypeImportant
- rs28371733G;GHomozygous for non-functioning CYP2D6*4H variant.Important
- rs1135840G;GHomozygous for CYP2D6 variants (non-CYP2D6*1)Worth knowing
- rs5030656-;-CYP2D6*9 homozygoteWorth knowing
Notes
From SNPedia
Notes
rs72549354 represents a rare variation in CYP2D6 gene that is characteristic of the CYP2D6*20 allele. In dbSNP, the common (major) allele is represented by (-), and the rare variant allele introducing a single inserted nucleotide is represented as (C).
-;C
see discussion at rs72549354 and at CYP2D6
C;C
see discussion at rs72549354 and at CYP2D6
Source and license
Adapted from rs72549354 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.