rs28371733
A SNP in the LOC102723722 gene on chromosome 22. Its most notable genotype is G;G: Homozygous for non-functioning CYP2D6*4H variant.
- Gene
- LOC102723722
- Location
- Chr 2242,126,914 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- 23andMe
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TNot ratedHomozygous for CYP2D6*52 variant.
- C;TNot ratedCarrier of one CYP2D6*52 variant.
- G;GMost notableNot ratedHomozygous for non-functioning CYP2D6*4H variant.
- C;GNot ratedCarrier of one CYP2D6*4H non-functioning variant.
- C;CGoodnormal
SNPedia records rs28371733 on the minus strand: (A;A), (A;G), (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other LOC102723722 SNPs
- rs1135824C;CTwo copies of CYP2D6*3B non-functioning variantVery important
- rs5030867G;GCYP2D6*7 homozygoteVery important
- rs1065852A;AHomozygous for CYP2D6 decreased or non-functioning variants; possibly less response to some drugs, including tamoxifenImportant
- rs3892097T;TCYP2D6 poor metabolizer; many associations related to drug metabolismImportant
- rs5030655-;-CYP2D6*6 poor metabolizer phenotypeImportant
- rs72549354C;CTwo CYP2D6*20 alleles; significantly lowered metabolism of certain drugsImportant
- rs1135840G;GHomozygous for CYP2D6 variants (non-CYP2D6*1)Worth knowing
- rs5030656-;-CYP2D6*9 homozygoteWorth knowing
Notes
From SNPedia
Notes
The wild type allele for this SNP is (G) in minus orientation. When it changes to (C) it is known as 3877G>C and is a marker for non-functioning variant CYP2D6*4H. When it changes to (A) it is known as 3877G>A and is a marker for variant CYP2D6*52 which is possibly a decreased functioning variant, though more study is needed. Please note that this is in minus orientation and the 3877G>C version is subject to ambiguous flip.
T;T
This variant possibly has decreased CYP2D6 function, but current research is limited.
C;T
This variant possibly has decreased CYP2D6 function, but current research is limited.
Source and license
Adapted from rs28371733 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.